List of Billboard Rhythmic number-one songs of the 2000s

The Rhythmic chart debuted in Billboard Magazine in the issue dated October 3, 1992, as the Top 40/Rhythm-Crossover chart. Weekly rankings are "compiled from a national sample of airplay" as measured by Nielsen BDS monitoring rhythmic radios stations continuously.

At the start of the 2000s decade, the chart was called the Rhythmic Top 40 and was published in Airplay Monitor and online, available only to subscribers to Billboard. The chart returned to the print edition of Billboard Magazine in its August 2, 2003, issue. It was renamed to Rhythmic Airplay with the issue dated February 7, 2004. Since July 12, 2008, the chart has been called Rhythmic.

Below are the songs that reached number one on the chart from the beginning of the year 2000 to the end of 2009 in chronological order. The song to spend the most weeks at number one during the decade was "Lollipop" by Lil Wayne and featuring Static Major with a 12-week run.